Patients on dialysis typically have the following clearance of medications compared to normal patients:

Patients on dialysis generally exhibit slower clearance of medications compared to normal patients. This occurs because the kidneys, which are responsible for filtering and excreting many medications and their metabolites, are not functioning adequately in dialysis patients.

In individuals with healthy kidney function, medications are cleared effectively through renal pathways. However, in patients undergoing dialysis, the clearance can be impaired due to several factors, including altered pharmacokinetics and the presence of uremic toxins. While dialysis can assist in the removal of some drugs, the overall ability to clear substances from the bloodstream tends to be less efficient compared to individuals with fully functioning kidneys. This is particularly true for drugs that are predominantly eliminated through renal mechanisms.

Understanding the pharmacologic implications of dialysis is crucial for healthcare providers, as it influences dosing regimens and the potential accumulation of drugs that could lead to toxicity or adverse effects.